PARP as a Therapeutic Target

Recent research in cell death mechanism has rekindled interest in PARP’s (poly(ADP-ribose)polymerase) intriguing role in necrosis and apoptosis. This book covers the clinical aspects of PARP inhibitors, a promising class of drugs that counteracts the damage done by free radicals. International experts currently working on ways to apply it discuss its therapeutic potential in various forms of ischemia, diabetes, arthritis, inflammatory bowel disease, and septic shock.

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